We would like to invite you to participate in a new research study that examines how brain function may differ between children with and without ADHD. This research project aims to discover which parts of the brain are responsible for certain mental functions, and how these functions are influenced by stimulant medication and genetic factors. Your participation is valuable in advancing our knowledge about ADHD.

The study involves two visits to Georgetown University Medical Center: one session on medication and one session off medication. The off-medication session can be scheduled when your child's medication is routinely stopped (e.g. weekends). Each session will last for about two hours and parking a nominal amount of $30/hour will be provided. The study may also involve a third visit for the collection of a DNA sample, either via blood draw or cheek swab, as well as some paper/pencil testing. On the other visits, your child will play computer games examining certain mental functions while we take pictures of his/her brain in an MRI scanner. This scan does not involve radiation. MRI imaging is routinely used in hospitals for people of all ages and is considered to be safe and non-invasive to the child. We have ongoing studies using MRI imaging in children with other disorders such as autism and epilepsy, and in our experience, most children have enjoyed the experience. Each scan lasts for about 5 minutes, after which the child can take a break if necessary.

Eligibility Criteria 

• children ages 7-12 diagnosed with ADHD 
• taking stimulant medication
• free from any seizure disorder or other significant medical disorder 
• IQ > 85 and no known learning disorders

Exclusion Criteria 

• Any implanted metal or electrical device within the body or any permanent metal on or inside his/her body such as metal rods or screws due to past surgery, or orthodontic braces 
•  history of any other neurological or psychiatric disorder 
• use of any other psychotropic medication 
• dyslexia or other learning disorder; IQ < 85